Synthesis Of Peptides
The capped pieces did not react at the N incurable with the base-labile cleavable linkers, presented in the last combining as a catch tag to be recognized by the oxime-based and hydrazone-based ligation chemistry (Fig. 21). Cleavage was executed utilizing a TFA/TIS/H2O mixture, affording the unrefined pentapeptide H-Tyr-Ser-Ser-Phe-Leu-NH2 and the straight octreotate amide with 94% …